Developing a rash after starting Darzalex (daratumumab) injections is actually a known side effect. Skin redness, discoloration, and rash are listed among the common side effects of this treatment. Since it's given as an injection under the skin, local and broader skin reactions can occur.
Dexamethasone (a corticosteroid) Show Full Answer
Developing a rash after starting Darzalex (daratumumab) injections is actually a known side effect. Skin redness, discoloration, and rash are listed among the common side effects of this treatment. Since it's given as an injection under the skin, local and broader skin reactions can occur.
Dexamethasone (a corticosteroid) can also contribute to skin changes, which may explain why the rash appeared after a few weeks rather than immediately. Here are some steps worth considering:
- Tell your oncologist right away — they need to know about any new skin changes, especially ones that appear suddenly
- Don't self-treat without checking first, as some over-the-counter creams or antihistamines may interact with current medications
- Note when the rash appears — whether it's right after injection days or later in the cycle, as this helps your care team pinpoint the cause
- Ask about injection site changes — one MyMyelomaTeam member found that switching their injection location significantly reduced skin reactions
Your care team may suggest a topical cream or antihistamine, but let them guide that decision. The rash may be manageable without changing your treatment plan.
4 days ago
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