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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Is it normal to get a rash while doing darzalex injections and dexamethasone on day 2 and 3? Waiting on my oncologist office to call back.

A MyMyelomaTeam Member asked a question 💭
Laporte, IN
August 31
 · 
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A MyMyelomaTeam Member

Yes, thank you. This is the second time this has happened, I've been taking benadryl and it has helped. My shot are every other week and won't do monthly ones until November. Thanks

August 31
A MyMyelomaTeam Member

Melanie,
I did have a rash from my face to my torso. It happened several times. They pretreated me with Zyrtec and Pepcid and at the center I received Singular. The Pepcid has Famotidine which helped.. I repeated the 2 meds the following day and my rash went away! So this is my routine every month I get the Darzalex . I hope this helps. Maybe your Doctor will agree with treatment?? Good luck, I know it is miserable!!

August 31 (edited)
MyMyelomaTeam

Rashes are a known side effect of myeloma treatments, so what's being experienced isn't unusual. Both Darzalex (daratumumab) and dexamethasone can contribute to skin reactions, including rashes and redness, especially around injection sites.

Some things to watch for while waiting to hear back:

- Mild redness or irritation Show Full Answer

Rashes are a known side effect of myeloma treatments, so what's being experienced isn't unusual. Both Darzalex (daratumumab) and dexamethasone can contribute to skin reactions, including rashes and redness, especially around injection sites.

Some things to watch for while waiting to hear back:

- Mild redness or irritation at the injection site is common
- Spreading rash, hives, or swelling should be flagged as urgent
- Breathing difficulty or dizziness alongside a rash needs immediate medical attention — don't wait for a callback in that case A MyMyelomaTeam member shared a helpful tip about injection-related reactions — switching the injection site (for example, from the abdomen to below the shoulder) made a big difference in reducing side effects and pain.

It's great that the oncologist's office has already been contacted. They may suggest a topical treatment or adjust the approach. In the meantime, avoid using any over-the-counter creams or antihistamines without checking first, as they could interact with current medications.

August 31

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