Connect with others who understand.

  • Learn from expert-reviewed resources
  • Real advice from people who’ve been there
  • People who understand what you’re going through
Sign Up Log In
Powered By
Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 20
 · 
Be the first to react
A MyMyelomaTeam Member

I think the more you learn about, understand and track your blood test results the better decisions your can make. And you can ask your doctor informed questions.

My M-protein or M-spike is measured in the Serum Protein Electrophoresis (SPEP) test. Not everyones MM is measured using this test. For some the abnormal protein cells show up in the Serum Free Light Chain tests (Kappa to Lambda ratio).

For SPEP they measure abnormal monoclonal (or paraprotein) cells in 2 bands; Gamma and Beta regions. Your specific "bad" proteins should typically be in only one band. If they are showing up in a second band ask your doctor about this. My SPEP tests always have a comment from a doctor who analyzed the results and provides information on these measurements.

So make sure you can get a copy of these comments every time you get tested. And talk to your doctor to understand what region you and your team should be monitoring.

August 21
A MyMyelomaTeam Member

I learned the more you try to understand the labs the more upsetting you will get. You have to trust your oncology team. I do know it's difficult to deal with the disease we have MM. These expert doctors are well experienced in their field. I find my Mayo cancer team do monitor my monthly lab result trends. So I finally stopped questioning my monthly labs until at the quarterly appointment. I write my questions down each time and well prepared to ask at the appts.

August 20
MyMyelomaTeam

Being newly diagnosed and then hearing about a second M protein is understandably unsettling. It's important to know that M protein levels are one of the key tools doctors use to monitor myeloma — so detecting changes is actually the system working as it should.

M protein is an abnormal protein made by cancerous plasma Show Full Answer

Being newly diagnosed and then hearing about a second M protein is understandably unsettling. It's important to know that M protein levels are one of the key tools doctors use to monitor myeloma — so detecting changes is actually the system working as it should.

M protein is an abnormal protein made by cancerous plasma cells. Having it detected doesn't automatically mean things are getting worse, but it does give your care team valuable information about what's happening. Here's what your doctor will likely be looking at:

- Type of M protein — there are different types (IgG, IgA, IgM, etc.), and knowing which ones are present helps guide treatment decisions
- Levels — how much M protein is present matters, and your doctor will track changes over time
- Trends — whether levels are rising, stable, or falling is key to understanding how myeloma is behaving

The most important next step is to have a thorough conversation with your care team. They can interpret these results in the full context of your diagnosis and treatment history. Don't hesitate to ask them to explain what the second M protein means specifically for your situation.

August 20
A MyMyelomaTeam Member

Thank you ❤️

August 21

Related Questions

View All
A MyMyelomaTeam Member asked a question 💭

A MyMyelomaTeam Member asked a question 💭
Lincoln, NE