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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Hello, has anyone started teclistamab and how was the experience

A MyMyelomaTeam Member asked a question 💭
Kenya
August 9
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A MyMyelomaTeam Member

Hi Ferzin. I’m currently being treated with teclistamab, along with daratumumab, for relapsed multiple myeloma. I went through the teclistamab step-up dosing and am now in Cycle 2.

My experience has been surprisingly good. After my first step-up dose I had a mild CRS reaction during the night — fever around 101–102°F and body aches. Tylenol and dexamethasone took care of it. After the second step-up dose I only reached about 99°F, and after the final step-up dose I had no significant reaction.

Since reaching the full treatment dose, I’ve had essentially no noticeable side effects. In fact, at first that actually made me wonder whether the treatment was doing anything.

It certainly was. My kappa free light chain, which had been rising with my relapse, dropped to 0.06 on my most recent test. Both of my light chains are now extremely low.

Everyone responds differently, of course, and your medical team will watch closely for CRS, neurological effects, infections and low blood counts. But from one person actually taking teclistamab to another person considering it, my experience so far has been very positive.

Best wishes with your treatment.
Jeff

August 11
MyMyelomaTeam

Great question! Teclistamab (Tecvayli) is a bispecific antibody treatment that works by connecting your immune system's T cells directly to myeloma cells, helping your body attack them. It's FDA-approved for relapsed or refractory myeloma.

While specific member experiences aren't available right now, what is known from Show Full Answer

Great question! Teclistamab (Tecvayli) is a bispecific antibody treatment that works by connecting your immune system's T cells directly to myeloma cells, helping your body attack them. It's FDA-approved for relapsed or refractory myeloma.

While specific member experiences aren't available right now, what is known from clinical trials can give a helpful picture of what to expect. In studies, commonly reported side effects included:

- Infections (like upper respiratory infections or pneumonia)
- Cough
- Diarrhea
- Muscle or bone pain
- Fatigue
- Fever
- Headache
- Nausea
- Injection site reactions

Some more serious side effects can occur, including severe infections, critically low blood cell counts, and a reaction called cytokine release syndrome (CRS), which can cause fever, chills, or breathing difficulties. It's important to report any new symptoms to your care team promptly. On the positive side, clinical trials showed an overall response rate of around 62 percent when used alone, and when combined with daratumumab (Darzalex Faspro), results were even more impressive — including an 83 percent reduction in the risk of disease progression or death.

Talking with your oncologist about whether teclistamab is right for your situation is always the best next step!

August 9

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