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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 6
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Can Certain Medications Raise the Risk for Developing Myeloma? Read Article...
A MyMyelomaTeam Member

Dexamethasone is not known to cause multiple myeloma. In fact, it has been used for decades as part of multiple myeloma treatment. It is a corticosteroid and can have significant side effects, particularly with higher doses or prolonged use, which is why doctors increasingly try to minimize steroid exposure when appropriate. But those risks should not be confused with dexamethasone causing the myeloma itself. If you saw a source specifically claiming that dexamethasone causes MM, I’d be interested in seeing the source because that is not the established medical understanding.

August 11
A MyMyelomaTeam Member

I took a high corticosteroid for almost 2 years and quit because I felt like I was dying. A month or so later, I was diagnosed with MGUS.

August 6 (edited)
MyMyelomaTeam

That confusion is totally understandable — it does seem like a contradiction at first glance! Here's the key thing to know: an older 2006 study suggested a possible link between prednisone (a steroid) and myeloma risk, but more recent research has NOT confirmed that connection.

So the "steroids cause myeloma" idea hasn't Show Full Answer

That confusion is totally understandable — it does seem like a contradiction at first glance! Here's the key thing to know: an older 2006 study suggested a possible link between prednisone (a steroid) and myeloma risk, but more recent research has NOT confirmed that connection.

So the "steroids cause myeloma" idea hasn't held up under closer scientific scrutiny. As for why steroids like dexamethasone are used to *treat* myeloma, they actually serve a very different purpose in that context:

- They help reduce inflammation
- They can slow or kill myeloma cells
- They help manage side effects from chemotherapy

Think of it like this — the same water that causes flooding can also put out a fire. Context matters a lot in medicine!

That said, long-term steroid use does carry risks like immune suppression and bone weakening, which is worth discussing with your care team.

August 6

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