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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
June 19
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A MyMyelomaTeam Member

Tina,
I’m sorry to hear they are back. @A MyMyelomaTeam Member had MM in his shoulder and did not have radiation, just treatment- Darzalex FasPro and probably others with it. Check out his story. I’m sure he has detailed it. His Radiologist said radiation turns “Bone to Stone.”
Paula🌹

June 20 (edited)
MyMyelomaTeam

It's really tough when something you thought was dealt with comes back — and you're definitely not alone in dealing with lytic lesions returning.

Lytic lesions are a common complication of myeloma. The myeloma cells erode bone tissue, creating weak spots that can cause pain and increase fracture risk. Because myeloma is Show Full Answer

It's really tough when something you thought was dealt with comes back — and you're definitely not alone in dealing with lytic lesions returning.

Lytic lesions are a common complication of myeloma. The myeloma cells erode bone tissue, creating weak spots that can cause pain and increase fracture risk. Because myeloma is typically a whole-body condition, lesions can reappear even after being treated locally. Here are some important things to know about recurring lesions:

- Local treatments like the procedure your pain management doctor performed can target specific painful areas
- Whole-body treatments (systemic myeloma therapies) are often needed to address the underlying cause and help prevent new or recurring lesions
- Bisphosphonate medications may be recommended alongside myeloma treatment to help strengthen bones and reduce fracture risk
- Fracture risk is real — weakened bones can break even without a significant injury, so it's important to flag this quickly

The most important next step is to contact your myeloma specialist as soon as possible. They can assess whether your current treatment plan needs adjusting to better control the disease that's driving these lesions.

June 19

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Kingman, AZ