I have a bone marrow transplant next week. Do I agree to the procedure?
Answer Summary
Members responded to a question about whether to agree to a bone marrow transplant, with many sharing that age and overall health are key... Read more
Donna, I'm a case study of one. I was rejected for SCT in 2008, and told I had 'six months, maybe' left. 2 years later, 2010, I'm off all chemo. It got both knees and 5" of spine.
I don't think anyone really wants a stem cell transplant, but if you have high risk myeloma and aren't getting to MRD negativity with induction m, it's an option. What does your myeloma specialist say.
Because your young is the main reason most likely they want you do to this, its much safer when the person is young and healthy otherwise. I am 57 and I am scheduled for this in the next couple of months because I'm healthy and still young enough. It really depends on your situation, some people choose to just do the treatments and they are doing fine. My Myeloma is still in MGUS stage, but I'm leaking protein from the myeloma cells into my blood which is called Light Chains Deposition Disease and it's affecting my kidneys. I've been lucky as I was diagnosed 11 years ago with this and haven't had to do treatment this whole time as my kidneys stayed stable enough. Now my doctors are worried that could change. I asked just yesterday during an appointment with my Oncologist is there any other options, she stated I could stay on treatment but doesn't feel because of my situation the best long term solution, the bone marrow doctor stated the same thing when I met with him in December, he felt that I have a great chance for long term remission because I'm still MGUS and my plasma level is still under 10%. There's a chance even after the transplant I will have to stay maintenance for the rest of my life, but there are those that maintenance is no longer needed after transplant after a period of time, that's what I'm hoping for. I've had a 50% response so far to treatment, meaning my light chain number have decreased 50% through 3 cycles so they are very encouraged by the results and my kidney health via blood work has increased over 20%, so treatment is working. But I don't feel a long term remission at this time is as probable without a transplant, some people go into remission for 10, 15, even 20 years or more after a transplant, it's really an individual thing and how aggressive your myeloma is. I just saw a video from the myeloma foundation of a guy who's been in remission for 25 years after his transplant. That's what I'm hoping for, time will tell. I don't really want to do the transplant either, but having my kidneys fail is much worse conclusion in my opinion. I've talked with quite a few people that have been through the transplant and they have all said they are glad they did it, they all stated there's about a 3-4 day period where it really sucks but once your past that, it's not that bad. I was able to find a mentor via the City of Hope where I'm getting my transplant done and he was around my age when he got his transplant but was much worse off than me, he was 90% plasma cells with vertebra collapse, he really answered a lot of questions for me and and painted a picture of what to expect and also hooked me up with a local support group that I joined a meeting with last weekend and they answered some other questions I still had. The leader of that group is much older than me and he has been in remission for 12 years. This all sucks anyway you look at it, but I've resolved my self and mentally it's helped me find peace.
They turned me down for SCT in 2008. I was off chemo in 2010. '84, shooting for 100.
Aldisugi, I assume by bone marrow transplant you mean an autologous stem cell transplant for myeloma? Where they harvest and give back your stem cells after you get high dose Melphalan. They usually don't do donor transplants for myeloma. Yes, I had an autologous stem cell transplant back in 2017. It was a good option for me since I am high risk and the drugs weren't controlling my myeloma that well.
You do have to sign a consent for the procedure. It's kind of a big deal. The doctor is supposed to explain the pros and cons of transplant before you sign the consent. They do wipe out most of yor healthy bone marrow as well as the myeloma cells. Your immune system will be compromised for at least 3 months. You will need to get all your childhood vaccines again.
Your doctors should be discussing all this with you. Some people are reaching mrd negativity with out transplant. You should ask about your MRD status. Please go to the Healthtree Foundation website. They have learning modules that tell all about transplant for myeloma. Good luck