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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

What is the usual therapy if relapsing after Revlimid / lenalidomide?

A MyMyelomaTeam Member asked a question 💭
Harpers Ferry, IA

Diagnosed in 2020. I had a bone marrow transplant in 2021, Revlimid, and now I am relapsing. Seeing my doctor soon.

April 3
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3 Stages of Myeloma: Understanding Progression Read Article...
A MyMyelomaTeam Member

Ahh, Nancy, you're a mere child. I'm 84, and I think lots of folks here are going to die of something other than MM. I've been away from it for over 16 years. Shooting for 100.

April 8
A MyMyelomaTeam Member

My husband will be starting immunotherapy. There are different treatments. I did my research and we chose the best for him at 82. He started his treatment journey at 74. Cart T is the best. But because of his age it was a no for us.

April 3
A MyMyelomaTeam Member

I’m 74 now. I’m waiting to see what my doctor recommends next month. Every case is different and I may be too old for Car-T ??? It was not the recommended treatment when I had my SCT. The tech with me during cell withdrawal said that Car-T could someday be the “answer” for lots of cancers. He was very optimistic.

April 7
MyMyelomaTeam

What treatment options are available if you're relapsing after Revlimid/lenalidomide?

When myeloma no longer responds to lenalidomide, doctors typically switch to different drug classes. The most common approach combines proteasome inhibitors and monoclonal antibodies.

Here are the main treatment combinations your doctor Show Full Answer

What treatment options are available if you're relapsing after Revlimid/lenalidomide?

When myeloma no longer responds to lenalidomide, doctors typically switch to different drug classes. The most common approach combines proteasome inhibitors and monoclonal antibodies.

Here are the main treatment combinations your doctor might discuss:

* DVd (daratumumab, bortezomib, and dexamethasone) - proven to extend survival and delay relapse
* DPd (daratumumab, pomalidomide, and dexamethasone) - works well for those previously treated with lenalidomide
* IsaPd (isatuximab-irfc, pomalidomide, and dexamethasone) - especially helpful for high-risk individuals or those with kidney issues
* VPd (bortezomib, pomalidomide, and dexamethasone) - a good alternative when daratumumab isn't an option

Your doctor will consider several factors when creating your treatment plan, including your overall health, how well previous treatments worked, and how long you were in remission after your transplant.

Since you're seeing your doctor soon, they'll review your specific situation and recommend the best approach for you. The goal is to regain control of the disease quickly while minimizing side effects and maintaining your quality of life.

April 3

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