Hi Viswanadhank, they can add medicine like Darzalex faspro to the Pomalyst or start another treatment all together.

Hi ViswanadhanK 🙏

I understand your concern — when a maintenance medication like Pomalidomide (2 mg) isn’t controlling the myeloma as expected and pain is increasing, it’s important to talk to your hematologist or oncologist as soon as possible.

Every patient’s myeloma journey is different, and the next steps depend on your current blood work, scans, side effects, and overall health. Some options your doctor might consider (depending on your situation) include:
• Adjusting the dose of Pomalidomide
• Switching to or combining with other therapies (like Revlimid, Kyprolis, Velcade, or new targeted drugs)
• Considering clinical trials or newer immunotherapies

💡 Important: Never change or stop your medicine on your own. Even low doses can affect the disease if stopped suddenly.

Also, for leg pain, your doctor can help determine if it’s neuropathy from treatment, bone pain from myeloma, or something else — and adjust medications to manage it safely.

The best next step is to call your care team, explain the symptoms, and ask about alternative or next-line treatments.
I completely understand. I’m having a similar problem with my leg pain while on maintenance treatment. It can be frustrating and uncomfortable, especially when the medicine doesn’t seem to be working as well as before.
I taking VRd and Valcade injection every 2 weeks
Like you, I make sure to track my symptoms carefully and stay in close contact with my doctor. They can help decide if the dose needs adjusting, a different medicine should be tried, or additional medication needed

🩸😕🙏
Mohammad

Thank you. I cannot afford the cost of Darzalex faspro as this cost around Rs. 2 lakh. (Around USD 2000) per unit. My family annual income is around USD 3000. I can afford only upto Carfilzomib, cost is around USD 100 per bottle, which is in the eligibility list of free for the persons, below poverty line, by federal government under free insurance of INR 5 Lakh (USD 5000) per year and renews every year. Again thank you very much for your suggestion.