What treatment options are available for high-risk smoldering multiple myeloma (SMM)?
First, it's important to understand that high-risk SMM is defined by specific criteria, including having high levels of serum M protein in your blood. Recent evidence suggests that early treatment may improve outcomes, particularly for Show Full Answer
What treatment options are available for high-risk smoldering multiple myeloma (SMM)?
First, it's important to understand that high-risk SMM is defined by specific criteria, including having high levels of serum M protein in your blood. Recent evidence suggests that early treatment may improve outcomes, particularly for people with high-risk SMM who are more likely to progress to active multiple myeloma.
Treatment approaches for high-risk SMM may include:
* Lenalidomide (Revlimid) combined with low-dose dexamethasone (Decadron) - clinical trials have shown this combination may reduce the chances of developing active myeloma
* Bisphosphonates like pamidronate (Aredia), denosumab (Xgeva), or zoledronic acid (Zometa) - these strengthen bones and protect against bone damage
Some people with lower-risk SMM may follow a "watchful waiting" approach with close monitoring instead of immediate treatment. This avoids treatment side effects while carefully tracking for any progression.
Your healthcare team will determine the best approach based on your specific risk factors, overall health, and test results. Make sure to discuss your treatment goals with your oncologist and ask questions about what criteria they're using to guide treatment decisions.
February 2
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