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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMyelomaTeam Member asked a question 💭
December 23, 2025
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A MyMyelomaTeam Member

Ironically enough long before I was diagnosis with MGUS I had several blood tests that showed low white cell counts. The doctors never knew why this happened but eventually they returned to normal. I often have wondered if the low white blood count was a warning sign of things to come.

December 24, 2025
MyMyelomaTeam

Are low neutrophils an early sign of myeloma?

Low neutrophils (a type of white blood cell) can be associated with myeloma, but they're not typically considered an early warning sign. In the early stages, myeloma often causes no symptoms at all, or only very mild ones.

As myeloma progresses, it can cause low white blood Show Full Answer

Are low neutrophils an early sign of myeloma?

Low neutrophils (a type of white blood cell) can be associated with myeloma, but they're not typically considered an early warning sign. In the early stages, myeloma often causes no symptoms at all, or only very mild ones.

As myeloma progresses, it can cause low white blood cell counts (leukopenia) because the abnormal plasma cells crowd out healthy blood cells in the bone marrow. This includes neutrophils, which are important for fighting infections.

However, low neutrophils alone aren't specific to myeloma. If you're experiencing low neutrophil counts, your doctor will likely look at other factors to determine the cause, such as:

* Other blood cell counts (red blood cells and platelets)
* Calcium levels
* Kidney function tests
* Presence of abnormal proteins (M proteins)
* Bone marrow examination

Early detection of myeloma usually happens through blood tests that show abnormalities like anemia, high calcium levels, or the presence of M proteins, rather than low neutrophils specifically.

If you're concerned about your neutrophil levels, it's important to discuss this with your healthcare provider who can evaluate your complete blood work and determine if further testing is needed.

December 23, 2025

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A MyMyelomaTeam Member asked a question 💭