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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
December 9, 2025
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A MyMyelomaTeam Member

Tammy, it takes a myeloma specialist and an experienced radiologist to figure out our labs/imaging. Getting a myeloma specialist is very important with this disease.

December 9, 2025
A MyMyelomaTeam Member

Tammy,
I thought any Oncologist could treat me, but I found out I needed a Hematologist/Oncologist who specializes in MM. Check out your doctor on line. Also, before any treatment, it is custom to get a second opinion.
Paula🌹

December 11, 2025
MyMyelomaTeam

How do smoldering multiple myeloma, sclerotic lesions, PET scans, and an M spike of 2.1 relate to each other?

Smoldering multiple myeloma (SMM) is a precancerous condition where you have higher levels of abnormal plasma cells and M protein, but without symptoms or organ damage. Your M spike of 2.1 indicates the level of M Show Full Answer

How do smoldering multiple myeloma, sclerotic lesions, PET scans, and an M spike of 2.1 relate to each other?

Smoldering multiple myeloma (SMM) is a precancerous condition where you have higher levels of abnormal plasma cells and M protein, but without symptoms or organ damage. Your M spike of 2.1 indicates the level of M protein in your blood, which is one of the key markers doctors use to monitor SMM.

PET scans help determine the extent of disease and can visualize bone lesions. Finding bone lesions on imaging tests like PET scans is significant because it can change your diagnosis from smoldering myeloma to active multiple myeloma.

Sclerotic lesions (areas of abnormal bone density) found on a PET scan, combined with your M spike level, help your doctor assess:
- Whether SMM is progressing toward active myeloma
- The overall disease burden in your body
- Whether treatment should begin

The presence of bone lesions is one of the specific abnormalities that may lead to a diagnosis of active multiple myeloma rather than SMM. Regular monitoring through imaging and M protein tests helps catch any progression early.

December 9, 2025

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