The lenolidomide causes my toes and fingers to cramp, as well as my calves. I curl my toes and they sometimes give me a hard time unfurling. I massage my calves and that seems to hold the cramping at bay. As for my hands, I bought a set of six silicone eggs, different colors for different degrees of resistance. Black is the hardest. I vary the colors from day to day, but squeeze in each hand for about 15 minutes sometimes a bit longer. It definitely helps the hands from cramping. I bought the HiKeep HK Hand Exerciser Eggs 6 piece set .
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I did when I was first diagnosed. I think the steriods and Velcade contributed to the swelling. My oncologist would not let me take diuretics. I can't remember why. I think she was worried about my kidneys. I bought a recliner and kept my legs elevated. I also wore light compression hose.

Edema. I had it during induction and then with Pomalyst pretty bad. Lasix 1-3 times a day. Then this caused cramping due to loss of potassium so you have to take a supplement. Then too much potassium can cause constipation. It was a crazy balance.

I have not experienced swollen extremities, but my doctor examines my ankles on almost every visit,