Mine was down from Myeloma. Then it went down even more with treatments. Something could be going on in your bone marrow, etc. So you will need a workup to know what's going on.
November 21, 2025
Why are your white blood cell (WBC) count high and red blood cell (RBC) count low?
In myeloma, abnormal plasma cells multiply in the bone marrow and crowd out healthy blood cells. This crowding prevents your bone marrow from producing normal amounts of other cells, including red blood cells.
When myeloma cells take over Show Full Answer
Why are your white blood cell (WBC) count high and red blood cell (RBC) count low?
In myeloma, abnormal plasma cells multiply in the bone marrow and crowd out healthy blood cells. This crowding prevents your bone marrow from producing normal amounts of other cells, including red blood cells.
When myeloma cells take over space in the bone marrow, they compete with healthy blood cells. This leads to:
* Low red blood cell counts (anemia) - causing fatigue and weakness
* Changes in white blood cell levels - affecting your immune system
* Low platelet counts - increasing bruising and bleeding risk
The high WBC count might indicate several things related to myeloma. Sometimes it reflects the increased number of abnormal plasma cells (which are a type of white blood cell), or it could signal an infection your body is fighting - especially since myeloma weakens the immune system.
Low red blood cells (anemia) is one of the CRAB symptoms doctors look for in active myeloma. This combination of blood count changes is common and should be discussed with your healthcare team, as they can help determine if treatment adjustments are needed.
November 21, 2025
Ask your doctor right away. I thought only infections and Leukemia had high white blood cell counts.
Paula🌹
November 21, 2025 (edited)
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