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November 7, 2025
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What side effects have you experienced with Dara-RVD treatment?

Dara-RVD combines daratumumab (Darzalex) with lenalidomide (Revlimid), a steroid, and sometimes bortezomib (Velcade). Each component can cause different side effects.

Common side effects from daratumumab include
* Nausea
* Back pain
* Fever
* Cough
* Fatigue Show Full Answer

What side effects have you experienced with Dara-RVD treatment?

Dara-RVD combines daratumumab (Darzalex) with lenalidomide (Revlimid), a steroid, and sometimes bortezomib (Velcade). Each component can cause different side effects.

Common side effects from daratumumab include:
* Nausea
* Back pain
* Fever
* Cough
* Fatigue
* Low blood cell counts

Rarely, daratumumab may cause severe infusion reactions with breathing trouble and dizziness.

Lenalidomide can cause:
* Itchy rashes (reported in about 19% of people)
* Bleeding problems
* Infections
* Anemia
* Nerve damage
* Blood clots (taking aspirin or blood thinners may help reduce this risk)

Steroids in the regimen may lead to:
* Sleeping problems
* High blood sugar levels
* Weight gain
* Mood changes
* Bone weakening

If you're experiencing side effects, talk with your doctor. Your healthcare team can recommend treatments to manage these issues and improve your quality of life.

November 7, 2025

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