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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

lambda type of mm

A MyMyelomaTeam Member asked a question 💭
New York, NY

has anyone with aggressive mm, just had the front line drugs and DID not have stem cells and is doing well? can just the drug treatment make you go into remission?

November 4, 2025
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A MyMyelomaTeam Member

I had the BMT after the initial phase of faspro/velcade/lenolidomide. In fact, they withdrew enough stem cells to do twice. Dr. Lahoud is not a fan of CAR-T, so unfortunately should I relapse I would have to undergo another BMT. However, I would not get it, the melphalan knocked me on my ***, and going back to zero immunity is not something I'd rather go through again. So I would opt for something else.

November 4, 2025
A MyMyelomaTeam Member

Hi Liz, I have Lambda MM very aggressive stage 3 with the 17p deletion diagnosed in March '24 at age 67. I chose not to have an SCT because I am asymptomatic and want to work until 70, just turned 69 last week. I am still asymptomatic, tolerating the maintenance drugs of Revlimid & Darzalex faspro well have been in remission since August '24. I have a BMB scheduled for March '26 if I am negative, I will be taken off 1 of the maintenance drugs probably Darzalex faspro. Hoping it is so.

November 4, 2025
MyMyelomaTeam

Can first-line drug treatments alone achieve remission in aggressive multiple myeloma without stem cell transplant?

Yes, drug treatment alone can lead to remission for people with multiple myeloma. Many treatments can target and reduce cancer cells, helping manage symptoms and control the disease. These therapies allow Show Full Answer

Can first-line drug treatments alone achieve remission in aggressive multiple myeloma without stem cell transplant?

Yes, drug treatment alone can lead to remission for people with multiple myeloma. Many treatments can target and reduce cancer cells, helping manage symptoms and control the disease. These therapies allow many people to live in remission—where signs of cancer are greatly reduced or undetectable—for years, and sometimes even decades.

The standard first-line treatment involves triplet combinations of chemotherapy, immunomodulatory drugs, and proteasome inhibitors. When people don't undergo stem cell transplantation, the treatments following their first treatment phase are called continuous therapy, often using immunomodulatory drugs.

Recent studies have found that using newer medications as first-line treatment leads to better outcomes than traditional chemotherapy approaches. Stem cell transplants can provide additional benefits but typically only buy time, and myeloma usually comes back in a few years. However, transplants may not be an option for everyone, especially older individuals or those in worse health.

Some people achieve such deep remission that their cancer never returns, though it's important to discuss all treatment options with your doctor to understand what might work best for your specific situation.

November 4, 2025

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