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How IVIG can prevent relapse

A MyMyelomaTeam Member asked a question 💭
Lake Charles, LA

I am MRD-6, two years out from CAR-T therapy.

The chance of relapse naturally worries me.

I’ve been receiving IVIG due to low resistance to infection.

I learned that MCAS and myeloma share dysfunctional mast cell systems.

In myeloma, mast cells fail to protect against pathogens…

In MCAS, mast cells are in constant overdrive producing anti-histamines.

Interestingly, some people with MCAS get IVIG to control their debilitating symptoms.

I decided to explore this connection, and I think you’ll find it… read more

October 26, 2025
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Reactions
A MyMyelomaTeam Member

I'm also getting IVIG as I had one cold after another last winter which is unusual for me. A blood test revealed that my IgG numbers were low. So far no colds or infections.

October 27, 2025
A MyMyelomaTeam Member

Hi Amy, IVIG (intravenous immunoglobulin) infusions are donated antibodies. Since MM compromises the body’s immune system and MM meds can suppress a person’s immune system even more, people frequently end up fighting infections, respiratory flu, colds and viruses more than usual compared to healthy non-compromised people. If your Dr notices your antibodies are low, an infusion of IVIG would be a smart move, especially coming into the winter months when people move indoors from the winter, and colds and flu takeoff. I get a monthly infusion OCT- April. It’s a slow drip infusion which takes 1.5-2hrs to drain.

October 26, 2025
A MyMyelomaTeam Member

I've been getting IVIG because I kept getting sick. I haven't heard that it prevents relapse.

October 26, 2025
A MyMyelomaTeam Member

Hi, I’ve never heard of IVIG! Are you on it? Is it for us so we don’t
relapse?

Amy L. Salmon

October 26, 2025
MyMyelomaTeam

Can IVIG help prevent myeloma relapse by reducing inflammation?

It's great that you're two years out from CAR-T and maintaining MRD negativity — that's a significant milestone worth celebrating!

Your question about IVIG's potential role in preventing relapse through inflammation control is thoughtful. While IVIG is commonly Show Full Answer

Can IVIG help prevent myeloma relapse by reducing inflammation?

It's great that you're two years out from CAR-T and maintaining MRD negativity — that's a significant milestone worth celebrating!

Your question about IVIG's potential role in preventing relapse through inflammation control is thoughtful. While IVIG is commonly used in myeloma to prevent infections when antibody levels are low, current evidence focuses primarily on its immune-supportive role rather than direct relapse prevention.

Here's what we know about IVIG in myeloma:

Primary Use:
- IVIG provides donor antibodies to help prevent infections when your immune system produces insufficient antibodies
- It's administered regularly to increase antibody levels and lower infection risk

Regarding Relapse:
Even with MRD-negative status, there's still a possibility that undetectable myeloma cells remain in the body. Over time, these cells may regrow, causing relapse. Remission doesn't guarantee the cancer is completely gone.

The Inflammation Theory:
Your exploration of the LPS-inflammation connection is interesting, though there isn't established evidence in the search results showing IVIG directly prevents myeloma relapse through this mechanism.

Bottom Line:
Continue your IVIG as prescribed for infection prevention — that immune support is valuable. Discuss your theory with your oncologist, as they can evaluate any emerging research specific to your situation and help you understand all factors that might influence relapse risk.

You're taking proactive steps to understand your health, which is empowering!

October 26, 2025

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