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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMyelomaTeam Member asked a question 💭
Santa Monica, CA
October 23, 2025
 · 
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A MyMyelomaTeam Member

Yes, Revlimid is usually the culprit. I also got c diff diarrhea after my transplant. Tell you doctor. There are treatments.

October 23, 2025
A MyMyelomaTeam Member

@A MyMyelomaTeam Member
Yes it is especially taking Revlimid / Lenalidomide tell your oncologist there’s medication to help with it

October 23, 2025 (edited)
A MyMyelomaTeam Member

Yes, I had diarrhea so bad the first 6 months that I was on Revlimid and Velcade that I lost 60 pounds. When I was taken off Revlimid and Velcade, I started Darzalex injections and started gaining weight. I'm finally up to my goal weight of 115 pounds, and don't have the diarrhea since I began Darzalex treatment 2 years ago.

October 23, 2025
A MyMyelomaTeam Member

Diarrhea is a definite side effect of Revlimid / Lenalidomide and some of the anti-viral medications we are given.

October 23, 2025
MyMyelomaTeam

Yes, diarrhea is a common side effect of multiple myeloma and its treatments. Over 790 MyMyelomaTeam members have reported experiencing diarrhea or loose, watery stools. It can be particularly challenging during chemotherapy and may be severe enough to require treatment changes or delays. Revlimid (lenalidomide) in Show Full Answer

Yes, diarrhea is a common side effect of multiple myeloma and its treatments. Over 790 MyMyelomaTeam members have reported experiencing diarrhea or loose, watery stools. It can be particularly challenging during chemotherapy and may be severe enough to require treatment changes or delays. Revlimid (lenalidomide) in particular can cause late-onset diarrhea, typically appearing 17-24 months after starting treatment. Here are some strategies that may help manage diarrhea:

• Eating well-cooked vegetables
• Consuming peeled canned fruits
• Including white rice and bread in your diet
• Having yogurt
• Eating lean, skinless meats (baked or broiled)
• Having smooth peanut butter
• Eating cooked eggs (not fried)

Always consult your oncologist before taking any medications (including over-the-counter ones) or making dietary changes to manage symptoms.

October 23, 2025

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