What is the relationship between amyloidosis and myeloma?
AL amyloidosis and multiple myeloma are related conditions since both involve plasma cells producing abnormal proteins. While myeloma is considered a blood cancer, AL amyloidosis occurs when abnormal light chain proteins stick together and form deposits in body Show Full Answer
What is the relationship between amyloidosis and myeloma?
AL amyloidosis and multiple myeloma are related conditions since both involve plasma cells producing abnormal proteins. While myeloma is considered a blood cancer, AL amyloidosis occurs when abnormal light chain proteins stick together and form deposits in body tissues. These conditions can sometimes occur simultaneously.
Key differences:
• Myeloma involves more plasma cells in bone marrow
• Amyloidosis has lower levels of plasma cells but protein deposits affect organs
• Kidney damage occurs differently in each condition - through protein deposits in amyloidosis vs excess light chains or high calcium in myeloma Treatment approaches are similar for both conditions, including:
• Chemotherapy drugs like cyclophosphamide
• Targeted therapies such as Darzalex Faspro
• Immunomodulatory medications
• Autologous stem cell transplantation
The goal is to reduce abnormal plasma cells while managing symptoms. Your healthcare team will determine the most appropriate treatment plan based on your specific situation.
October 19, 2025
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