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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
September 29, 2025
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Maintenance therapy for multiple myeloma typically includes both oral and injectable medications. Common oral medications include:

• Immunomodulators like lenalidomide (Revlimid), thalidomide (Thalomid), and pomalidomide (Pomalyst)
• Corticosteroids like dexamethasone
• Injectable medications may be given through IV or Show Full Answer

Maintenance therapy for multiple myeloma typically includes both oral and injectable medications. Common oral medications include:

• Immunomodulators like lenalidomide (Revlimid), thalidomide (Thalomid), and pomalidomide (Pomalyst)
• Corticosteroids like dexamethasone
• Injectable medications may be given through IV or under the skin, such as Darzalex Faspro The duration of maintenance therapy has evolved over time. Current protocols suggest staying on maintenance therapy indefinitely as long as you tolerate it well. Research shows the effectiveness of medications like lenalidomide actually increases over time, with some patients achieving negative minimal residual disease (MRD) after 30 months of treatment.

It's crucial to stick to your prescribed maintenance schedule - studies show about 30% of patients don't follow their plan exactly, which can increase risk of recurrence. If you're having trouble maintaining your schedule, discuss this with your healthcare team.

September 29, 2025

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