Smoldering multiple myeloma (SMM) is a precancerous condition that can develop into active multiple myeloma. It's characterized by having higher levels of abnormal plasma cells and M protein than earlier precancerous conditions, but lower levels than active multiple myeloma.
Unlike active myeloma, SMM typically doesn't Show Full Answer
Smoldering multiple myeloma (SMM) is a precancerous condition that can develop into active multiple myeloma. It's characterized by having higher levels of abnormal plasma cells and M protein than earlier precancerous conditions, but lower levels than active multiple myeloma.
Unlike active myeloma, SMM typically doesn't cause symptoms. However, it's important to monitor closely as it can progress to active multiple myeloma. When SMM progresses to active multiple myeloma, doctors use the Revised International Staging System (R-ISS) to classify the disease into three stages based on:
• Blood test results
• Protein levels
• Genetic changes in cancer cells
Each stage reflects different severity levels and may require different treatment approaches. Regular monitoring helps track any progression from SMM to active myeloma stages.
September 17, 2025
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