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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
September 16, 2025
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MyMyelomaTeam

Pomalyst (pomalidomide) is an FDA-approved oral immunomodulator that is often prescribed along with dexamethasone when other therapies haven't been effective. Like Revlimid, it can cause some side effects that need to be monitored.

Common side effects of immunomodulator drugs like Pomalyst include
• Fatigue or drowsiness Show Full Answer

Pomalyst (pomalidomide) is an FDA-approved oral immunomodulator that is often prescribed along with dexamethasone when other therapies haven't been effective. Like Revlimid, it can cause some side effects that need to be monitored.

Common side effects of immunomodulator drugs like Pomalyst include:
• Fatigue or drowsiness
• Constipation
• Low blood cell counts
• Neuropathy
• Blood clots For comparison, Revlimid (lenalidomide) users commonly experience:
• Diarrhea or constipation
• Fatigue
• Swelling of extremities
• Insomnia
• Muscle cramps
• Digestive issues
• Respiratory infections
• Rash

It's important to discuss any side effects with your healthcare team, as they can often help manage troublesome symptoms and adjust treatment as needed.

September 16, 2025
A MyMyelomaTeam Member

Am on pomalidomide at the moment..most of the side effects are there including shortness of breath which may be due to carfilzomib too

September 16, 2025

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