IgG and IgA myeloma are defined by which type of abnormal antibody (immunoglobulin) is produced by the cancerous plasma cells. In multiple myeloma, these cells produce large quantities of abnormal antibodies that don't function correctly. These abnormal proteins are detected through specific blood and urine tests.
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IgG and IgA myeloma are defined by which type of abnormal antibody (immunoglobulin) is produced by the cancerous plasma cells. In multiple myeloma, these cells produce large quantities of abnormal antibodies that don't function correctly. These abnormal proteins are detected through specific blood and urine tests.
About half of myeloma cases involve abnormal IgG proteins, while approximately 20% (1 in 5) involve abnormal IgA proteins. The type of immunoglobulin can impact prognosis. IgA myeloma typically has a worse prognosis than IgG myeloma, with lower survival rates and a higher risk of relapse. This information helps doctors determine treatment approaches - those with IgA myeloma may receive more aggressive treatment plans.
Tests like immunofixation electrophoresis (IFE) and quantitative immunoglobulins tests are used to identify which specific type of immunoglobulin is present and measure their levels in blood or urine samples.
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IgG and IgA Antibodies: What Do They Mean?
September 6, 2025
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