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Does osteonecrosis, as a possible side-effect of Xgeva, only occur when teeth are extracted, or can it happen spontaneously, regardless of dental work?
@A MyMyelomaTeam Member - oh, it HASN'T happened to me, thankfully. At least not yet. I was just asking out of curiosity.
Osteonecrosis of the jaw (ONJ) can occur spontaneously, not just from dental extractions. This condition happens when the jaw bone becomes exposed inside the mouth and begins to die due to lack of blood supply. It's associated with medications like Xgeva (denosumab) and bisphosphonates used in myeloma treatment. Warning Show Full Answer
Why did you stop taking Xgeva? I was on it for 4 months and noticed an indentation between my upper jaw teeth. I had a bone graft and all seems to be ok at this point. I’m told by my MM specialist that I can go on Evenity, but again, I am concerned about side effects that can lead to ONJ. Any advice? Thank you!
Kappa,
I’m sorry if this has happened to you.💕❤️ Bisphosphonates are not the only solution. I was told I have severe osteoporosis in 2019 and they wanted me to start taking Zometa. Because of my other comorbidities, I decided to go the natural route and take Calcium, Magnesium, D3, K2, Collagen, and Vitamin C. So far only one tiny rib fracture from leaning over the trash can. I take about 1200 mg of MRM Bone Maximizer III, and take additional D3 & K2 and the others. You are not supposed to be on bisphosphonates more than two years, so 2019 felt too early to start for me.
Paula🌹
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