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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I am wondering about the Bone Modifying Agents used to treat the bone disease that MM causes. Has anyone had one of them?

A MyMyelomaTeam Member asked a question 💭
North Fort Myers, FL
June 18, 2025
 · 
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A MyMyelomaTeam Member

Bonnie,
I was diagnosed with severe osteoporosis in 2019 and they wanted me to go on these drugs. You can only be on them 2 years. They make your bones brittle and easier to break and also with MM you are higher risk of having osteonecrosis (a broken jaw bone). I decided for me, I would try calcium and magnesium supplements. I did not know about adding D3 & K2 supplements to help absorb the calcium and tell it to go to the bones. I take 4 capsules of MRM Bone Maximizer III with 2 extra capsules of D3 & K2 and collagen. Adding vitamin C helps too. I am doing well on this.
Paula🌹

June 18, 2025
A MyMyelomaTeam Member

I am on Zometa. I have the infusion every three months for two years. I have not experienced any problems with the first three treatments. Hoping that continues!

June 18, 2025
A MyMyelomaTeam Member

I truly hope people are listening to you... This is the perfect regimen! I believe God gave it you... God bless! ☺️❤️☺️

June 18, 2025
MyMyelomaTeam

Bone-modifying drugs like bisphosphonates and Xgeva (denosumab) are commonly used to prevent bone weakening, slow bone degradation, and control high calcium levels caused by multiple myeloma. Common bisphosphonates include:

• Aredia (pamidronate)
• Zometa (zoledronic acid)
• Bonefos (clodronate)
• Boniva (ibandronate)
• Show Full Answer

Bone-modifying drugs like bisphosphonates and Xgeva (denosumab) are commonly used to prevent bone weakening, slow bone degradation, and control high calcium levels caused by multiple myeloma. Common bisphosphonates include:

• Aredia (pamidronate)
• Zometa (zoledronic acid)
• Bonefos (clodronate)
• Boniva (ibandronate)
• Didronel (etidronate) Yes, MyMyelomaTeam members have experience with these medications. One member shared their experience taking Aredia as a bone-strengthening medication for several years. However, they were taken off it in 2015 due to a femur fracture that suggested they may have been on it too long. They now take an oral bone strengthener instead.

It's important to note that while these medications help protect bones, they require careful monitoring. Regular dental check-ups are essential as these drugs can sometimes affect bone healing, particularly after dental procedures.

June 18, 2025

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