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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
March 6, 2025
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A MyMyelomaTeam Member

My kappa light chains went up four points but that put me out of the normal range. My IGG is still low and my other tests seem ok. My ratio is high to 2.something. M spike test not in yet. Is there any other explanation for this besides relapse ?

September 15, 2025
A MyMyelomaTeam Member

Complete blood count, serum and urine protein electrophoresis, serum free light chains, maybe urine light chains, quantitative immunoglobins. I probably missed some but mainly the m spike and the free light chain test. They don't always make me do the 24 hour urine, but if they are worried about relapse I will probably do one. When I relapse the first time my m spike doubled. I know my specialist called me at home. Not a good sign. 🤔

March 6, 2025
MyMyelomaTeam

Doctors monitor for myeloma relapse through regular blood work and imaging tests. A relapse is typically diagnosed based on changes in blood globulin levels, new bone lesions, and increases in plasma cells in the bone marrow. Doctors use the CRAB criteria to check for relapse signs:

- Calcium levels (elevated)
- Renal Show Full Answer

Doctors monitor for myeloma relapse through regular blood work and imaging tests. A relapse is typically diagnosed based on changes in blood globulin levels, new bone lesions, and increases in plasma cells in the bone marrow. Doctors use the CRAB criteria to check for relapse signs:

- Calcium levels (elevated)
- Renal (kidney) function
- Anemia (decreased hemoglobin)
- Bone disease Minimal Residual Disease (MRD) testing is another important monitoring tool. This advanced testing uses next-generation sequencing or flow cytometry to look for remaining myeloma cells in the bone marrow. If MRD is detected after treatment, it may indicate a higher likelihood of earlier relapse. Regular imaging tests like X-rays, CT scans, MRI, and PET scans help track disease progression and treatment effectiveness.

March 6, 2025

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