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Need to get a second opinion for smoldering multiple myeloma

A MyMyelomaTeam Member asked a question 💭
Brandywine, MD
February 4, 2024
 · 
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MyMyelomaTeam

If you're seeking a second opinion for smoldering multiple myeloma (SMM), here are some key points to consider:

- Diagnosis: SMM is a precancerous condition that can lead to active multiple myeloma. It is often preceded by monoclonal gammopathy of unknown significance (MGUS)
- Monitoring: Regular follow-up visits and Show Full Answer

If you're seeking a second opinion for smoldering multiple myeloma (SMM), here are some key points to consider:

- Diagnosis: SMM is a precancerous condition that can lead to active multiple myeloma. It is often preceded by monoclonal gammopathy of unknown significance (MGUS).
- Monitoring: Regular follow-up visits and testing are crucial to monitor the condition's progress. This can help catch any progression to multiple myeloma early.
- Risk Factors: Certain factors increase the risk of SMM progressing to multiple myeloma, including:
- Plasma cells with specific gene changes
- High numbers of plasma cells in the bone marrow
- High levels of M protein
- M protein levels that increase over time
- M protein made from IgA heavy chain, rather than IgG
- Bone lesions visible on X-rays

- Treatment Options:
- Watchful Waiting: This approach involves regular monitoring without immediate treatment to avoid side effects.
- Bisphosphonates: Drugs like Aredia (pamidronate), Xgeva (denosumab), and Zometa (zoledronic acid) can strengthen bones and protect against damage.
- Early Treatment: For high-risk SMM, early treatment with drugs like Revlimid (lenalidomide) and low-dose Decadron (dexamethasone) may reduce the chances of developing multiple myeloma.

- Progression Rates:
- First 5 years after diagnosis: ~10% per year
- 5-10 years after diagnosis: ~3% per year
- 10+ years after diagnosis: ~1% per year

Consulting with a hematology and oncology specialist, such as Dr. Mark Levin, who has extensive experience in internal medicine, can provide valuable insights and a comprehensive evaluation of your condition.

August 2, 2024
A MyMyelomaTeam Member

Thanks made appointment to get a second opinion.

February 5, 2024
A MyMyelomaTeam Member

Cynthia,
I started with MGUS and had a bad bone marrow biopsy, which they would not repeat. I changed doctors and got a new bone marrow biopsy which showed I was Smoldering. You don’t have to change doctors to get a second opinion, you just find a MM Specialist and send them your records and meet them on a Zoom call or meet them in person. I changed doctors because I did not have confidence in them. I love my doctor at UCLA. Your doctor should be happy you are getting a second opinion because doctors just want you to have the best treatment. I found a video about it and it said the same thing. No one’s feelings will be hurt.
Paula🌹

February 5, 2024
A MyMyelomaTeam Member

I am quite new to this, but here is some information. https://www.mskcc.org/news/what-to-know-about-g...

Please note that I do not know anything about Memorial Sloan Kettering.

Getting a Second Opinion After a Cancer Diagnosis: 9 Things To Know
Getting a Second Opinion After a Cancer Diagnosis: 9 Things To Know
https://www.mskcc.org/news/what-to-know-about-getting-second-opinion-after-cancer-diagnosis
February 5, 2024

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