Steroids! Ask to drop the dose. See an endocrinologist.

It's usually the dexamethasone that gives us the big tummy and skinny arms and legs. I felt so bloated 😥

Rita,
All my pants are now stretchy. I have boxes of pants I can’t fit into. Steroids raise the blood sugar and they affected my adrenals. I now do not have any DHEA which is the fountain of youth. I have to take a supplement.
Paula 🌹

It is hard to tell, from what! We keep thinking it is the Dara or Ninlaro or the combination of both. He has been on Dex one way or another for 6 years. The tummy thing didn't start till Dara +. He takes a diuretic for fluid build up in his legs. To the point, now that he lets me buy him jeans and pants that are made with a stretchy fabric.😉

Rita,
It could be fluid build up, but I agree with Donna, it’s probably the Dexamethasone. When I Googled Dexamethasone, Goodrx.com says it’s a “long acting corticosteroid that is about 25 times more potent (stronger) than hydrocortisone and 6 times more potent than Prednisone”. I have Cushing’s Syndrome from a high corticosteroid steroid I used for 1 1/2 years. I started feeling bad and decided to stop taking it “cold turkey “. What a mistake. With high corticosteroids you have to slowly taper off them. Using less and less. All the fat in my arms and legs went to my stomach and chest. I have significant pericardial fat around my heart. It’s hard to breathe sometimes. It affected my heart. My blood was so thick, I would not bleed. I ended up having a heart attack. Your husband should talk to his doctor asap. His Pro-time should be checked. Dexamethasone helps with tumor burden and fighting cancer, but if the side effects are causing issues, another medication can be used. I went to Mass this morning, looking 6 months pregnant.
Paula 🌹