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A MyMyelomaTeam Member asked a question 💭

I’ve been on Darzalex/Revlimid/Dexamethasone for the last year and a half. I just received the latest Myeloma labs, and my M-Spike is down to 0.11. Serum immunoelectrophoresis identifies it as type IgG.kappa. All past M-Spikes were IgG.Lambda. I wonder if the IgG.kappa M-Spike is from the Darzalex, (a Kapa monoclonal protein) and that the IgG.Lambda M-Spike may be gone. Anybody experience this?

posted August 1, 2022
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A MyMyelomaTeam Member

If you’re M spike is that low. That sounds good to me

posted August 13, 2022
A MyMyelomaTeam Member

Hi @A MyMyelomaTeam Member Daratubanumb can cause a false positive IGG Kappa M spike. Some labs can differentiate this as being therapeutically caused. A special test has to be run to determine this.

posted August 2, 2022
A MyMyelomaTeam Member

Gail, so sorry you are going through all that
Hoping by now maybe you have support and a good plan with your oncologist
DPaul, I think you are right on point in the new Mspike that you are seeing is actually a therapeutic mono clonal spike that cannot be easily differentiated from one that is caused by myeloma
It’s obviously suspicious because it’s different than your original type of myeloma
They are trying to figure out how they will be able to differentiate from the M Spikes caused by Darzalex

One suggestion to maybe help:
Ask your physician to order a trough specimen for protein electrophoresis and IFE, just before the next dose, to minimize the possibility of detecting daratumumab.

posted May 17
A MyMyelomaTeam Member

just prayed 4u gailpricard3 an will continue

posted August 7, 2022
A MyMyelomaTeam Member

The Daratumab specific ife was not available at labs at the beginning of the year. I hope they have it now. I had an m spike on the kappa region too. I didn't worry since I am IgG Lambda😉

posted May 17

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