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M-Spike
I’ve been on Darzalex/Revlimid/Dexamethasone for the last year and a half. I just received the latest Myeloma labs, and my M-Spike is down to 0.11. Serum immunoelectrophoresis identifies it as type IgG.kappa. All past M-Spikes were IgG.Lambda. I wonder if the IgG.kappa M-Spike is from the Darzalex, (a Kapa monoclonal protein) and that the IgG.Lambda M-Spike may be gone. Anybody experience this?
Hi @A MyMyelomaTeam Member Daratubanumb can cause a false positive IGG Kappa M spike. Some labs can differentiate this as being therapeutically caused. A special test has to be run to determine this.
If you’re M spike is that low. That sounds good to me
Gail, so sorry you are going through all that
Hoping by now maybe you have support and a good plan with your oncologist
DPaul, I think you are right on point in the new Mspike that you are seeing is actually a therapeutic mono clonal spike that cannot be easily differentiated from one that is caused by myeloma
It’s obviously suspicious because it’s different than your original type of myeloma
They are trying to figure out how they will be able to differentiate from the M Spikes caused by Darzalex
One suggestion to maybe help:
Ask your physician to order a trough specimen for protein electrophoresis and IFE, just before the next dose, to minimize the possibility of detecting daratumumab.
just prayed 4u gailpricard3 an will continue
The term "M-spike" refers to the presence of monoclonal proteins (M proteins) in the blood, which can be detected through specific tests. Here are some key points about M-spike:
- Detection: M-spike is often identified using serum protein electrophoresis (SPEP), which separates proteins in the blood based on their Show Full Answer
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