That is a lot of Zometa. Zometa and Xgeva are used to maintain bone strength. The problem is that your bones can become so hard that osteonecrosis can occur. The bone can become so hard it cuts off the blood supply, and the bone dies. This is most common in the jaw. In my experience (8 years dealing with Multiple Myeloma, 8 times refractory, currently going through CAR T) Zometa or Xgeva are administered every three or four months. Lesions are not the exclusive reason for Zometa. The fact is that Myeloma attacks our bones, and the softer our bones, the easier they are to destroy. Zometa is also commonly used for those with osteporosis and other osseous afflictions. Xgeva is tailored more for Myeloma patients. I would definitely get some opinions. I have five oncologists and they don't always agree. Hugs.

Yes get an opinion from people who only do MM. MDAnderson in Houston or Roswell Cancer Center in Buffalo or Mayo Clinic. They have the most experience. Let a doctor from their group review and create your treatment plan with your local oncologist to implement. This is what I did and do far so good. Started two infusions weekly and two other cancer drugs.

Most myeloma specialists recommend bisphosphonates. The benefits outweigh the risks for most of us😍

I had similar situation with only one small bone lesion. They originally recommended one infusion per month but now to one every three months after my SCT with a calcium pill each day. Works great

My oncologist said the benefits of Zometa can last up to a year from the last infusion. I suspect that your doctor since you are newly diagnosed is taking the safe course until all the results are in. Just my opinion.