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Husband's most recent cytology report from his bone marrow biopsy said "Normal Male Karyotype, no clonal abnormalities detected." A FISH analysis was not done on this biopsy, probably because there were no abnormalities, but the original Fish analysis on the biopsy done at diagnosis, showed multiple chromosome deletions and alterations, leading to a "high risk" prognosis. This is also puzzling, since we were told that "high risk" suggests that the usual therapies do not work and multipleโฆ read more
Yes! I was told that I had a poor prognosis nine years ago due to my FISH results... I have never reached a zero on my M spike, just a one... but I am active and pain free and doing well.....๐๐๐๐
Darzalex is considered immunotherapy. It a monoclonal antibody. I've been on it 2 years. ๐
Anne, this is what the Emory doctors told me. Once high risk, always high risk. Since he doesn't have any myeloma in his biopsy sample there are no abnormal genes.๐ I understand that they are always there and can return๐ But praise God, that he responded so well to treatment. I finally got a normal bone marrow biopsy 2 years after transplant๐. Just hoping we both stay in remission. ๐๐๐ Did they do MRD testing?
Donna is correct. If there are no abnormal plasma cells detected, there is nothing to do FISH testing on. So he is now in complete remission and will hopefully stay that way forever. As long as the medications keep killing myeloma cells, he should stay in remission.
Update to my original question. Hubby has been in complete remission for two years. Still on first therapy in spite of high risk factors on original FISH. Every day is a blessing.
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