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Do FISH Results Showing Chromosome Deletions And Alterations Ever Change Back To Normal As A Result Of Chemo Treatments?

Do FISH Results Showing Chromosome Deletions And Alterations Ever Change Back To Normal As A Result Of Chemo Treatments?

Husband's most recent cytology report from his bone marrow biopsy said "Normal Male Karyotype, no clonal abnormalities detected." A FISH analysis was not done on this biopsy, probably because there were no abnormalities, but the original Fish analysis on the biopsy done at diagnosis, showed multiple chromosome deletions and alterations, leading to a "high risk" prognosis. This is also puzzling, since we were told that "high risk" suggests that the usual therapies do not work and multiple… read more

A MyMyelomaTeam Member said:

Darzalex is considered immunotherapy. It a monoclonal antibody. I've been on it 2 years. 💞

posted almost 2 years ago
A MyMyelomaTeam Member said:

Anne, this is what the Emory doctors told me. Once high risk, always high risk. Since he doesn't have any myeloma in his biopsy sample there are no abnormal genes.😇 I understand that they are always there and can return😖 But praise God, that he responded so well to treatment. I finally got a normal bone marrow biopsy 2 years after transplant😇. Just hoping we both stay in remission. 🙏🙏🙏 Did they do MRD testing?

edited, originally posted almost 2 years ago
A MyMyelomaTeam Member said:

Donna is correct. If there are no abnormal plasma cells detected, there is nothing to do FISH testing on. So he is now in complete remission and will hopefully stay that way forever. As long as the medications keep killing myeloma cells, he should stay in remission.

posted almost 2 years ago
A MyMyelomaTeam Member said:

My husband spent last Thursday in short stay unit of hospital receiving first IV of Darzalex. We were there from 6 am to 4 pm. He had no side effects. This Friday he gets his first IV of Darzalex, Velcade, Dexamethasone. He also takes 25 mg of Revlimid. We’re praying that this latest combination does the trick. Good luck on Friday!

posted over 1 year ago
A MyMyelomaTeam Member said:

My biopsy 6 months after my stem cell transplant showed the FISH to be normal also. I think that's the first time I have never been considered normal!! 😀😀

posted almost 2 years ago
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