Hypogammaglobulinemia is a long word but all it means is there is a problem with the a immune System. There are lower antibodies found that means there is a greater risk of infection. It is a deficiency of B Cells (B - Lymphocytes). It is an Immune System Defect - reduced Immune Function. Decreased Immunoglobulins. There are two kinds: Primary and Secondary.
Primary: It is associated by CD 21 gene abnormality.
Secondary; Is the result of another condition - an acquired immune deficiency, such as blood cancers; eg. Multiple Myeloma, Leukemia, Lymphoma, HIV, Organ Transplant, etc. or by Medications: eg Costicosteroids (dexamethasone), Chemo Drugs, Seizure Medications etc
It causes Chronic or Recurrent Infections: eg. bronchitis, ear infections, sinus infections, skin infections, etc.
If you have Hypogammaglobulinemia you must avoid Live Vaccines, use precautions, avoid travel to countries with epidemic diseases or poor sanitation.
Hypogammaglobulinemia presents with Chronic Infection. It is measured by your immunoglobulins. It is treated by a monthly infusion of IVIG (Gammaglobulins). mild allergic reactions are common
Prognosis: Increased IGG level -reduced infection.
**There is a new emerging therapy for Primary: Hematroietic Stem Cell Transplantation.
Love, Marcia

John,
Celgene (the maker of Revlimid and other MM drugs) has a great site you can join for free, www.myelomacentral.com. It gives you a library. One of the very useful articles is understanding your labs. Fool around with the drop down menu and you can browse around. If you like any of the articles just put it in your library and you can reference it, i have found it useful in understanding the various labs and their relationship to my MM. - Peter

I am being treated with monthly immunoglobulin for immune system deficiency with infusion. It helps buildthe immune system.

Mine often say that also and it is a result of the chemo. I think it is just a big fancy word to say your antibodies are deficient due to your chemo. If the doc isn’t concerned, I wouldn’t be either.

I go most places now cause my white blood cells are almost normal😁 Not everyone has low immunoglobulin s. I wash my hands a lot. I did wear a mask when I was neutropenic. You should know your labs