Finding IgA in the serum and Bence Jones proteins in the urine after being in remission post-ASCT is understandably concerning. These markers are ones that doctors watch closely when monitoring for signs of myeloma activity.
Here's what these findings can indicate:
- IgA in serum — IgA is a type of antibody that myeloma Show Full Answer
Finding IgA in the serum and Bence Jones proteins in the urine after being in remission post-ASCT is understandably concerning. These markers are ones that doctors watch closely when monitoring for signs of myeloma activity.
Here's what these findings can indicate:
- IgA in serum — IgA is a type of antibody that myeloma cells can produce. Its presence, especially if rising, may signal that myeloma cells are becoming active again
- Bence Jones proteins in urine — These are light chain proteins that can appear when myeloma cells are producing abnormal proteins, and they're a key marker doctors track
It's worth knowing that IgA myeloma can sometimes be trickier to measure on standard blood tests, as IgA proteins can sometimes mask the M protein spike doctors look for. This is why additional tests like quantitative immunoglobulin testing may be used alongside standard tests. Many MyMyelomaTeam members have shared similar experiences of seeing markers reappear after remission, and it's a situation that understandably brings a lot of anxiety.
The most important next step is to contact the oncology team as soon as possible. They'll likely look at:
- Whether these levels are new or rising compared to previous results
- Additional testing such as bone marrow biopsy or imaging
- Whether this signals a relapse or needs closer monitoring
Try not to jump to conclusions before speaking with the care team — sometimes results need context and comparison to previous labs to fully interpret. Reaching out to others on MyMyelomaTeam who've navigated similar moments can also be a great source of comfort and shared experience.
August 21
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