BiTE (Bispecific T-cell Engager) therapy is a newer treatment option, particularly for relapsed or refractory myeloma (RRMM). It works by acting like a bridge between your immune system and myeloma cells, helping your body's own defenses destroy the cancer.
BiTEs are given as injections under the skin, usually in the Show Full Answer
BiTE (Bispecific T-cell Engager) therapy is a newer treatment option, particularly for relapsed or refractory myeloma (RRMM). It works by acting like a bridge between your immune system and myeloma cells, helping your body's own defenses destroy the cancer.
BiTEs are given as injections under the skin, usually in the stomach or thigh. They can't be taken as a pill because stomach acid would break them down.
When starting treatment, the dose is gradually increased over the first one to two weeks. After reaching the full dose, injections are typically given once every one to four weeks. Like any treatment, BiTEs can come with side effects. Here are the most commonly reported ones:
- Cytokine release syndrome (an immune overreaction ranging from mild flu-like symptoms to more serious effects)
- Low blood cell counts
- Infections
- Fever
- Fatigue
- Nausea
- Headache
- Diarrhea
- Cough or shortness of breath
If taking talquetamab specifically, additional side effects may include:
- Nail changes
- Altered taste
- Weight loss
- Dry mouth
- Rash
A myeloma specialist will help weigh the potential benefits against these risks for the specific BiTE being considered. Always make sure to discuss any concerns with the care team before and during treatment.
August 4
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