It sounds like the diagnosis is IgG Lambda myeloma with normal FISH — let's break that down into plain language, because it's actually less scary once you understand the pieces!
IgG Lambda refers to the type of abnormal protein (called M protein) your myeloma cells are producing:
- IgG is the most common antibody type in Show Full Answer
It sounds like the diagnosis is IgG Lambda myeloma with normal FISH — let's break that down into plain language, because it's actually less scary once you understand the pieces!
IgG Lambda refers to the type of abnormal protein (called M protein) your myeloma cells are producing:
- IgG is the most common antibody type in myeloma — it's the type of immunoglobulin (immune protein) your abnormal plasma cells are making
- Lambda refers to the specific "light chain" attached to that antibody — there are two types, kappa and lambda, and yours is lambda Normal FISH is actually good news! FISH stands for Fluorescence In Situ Hybridization — it's a test that looks at the chromosomes inside your myeloma cells for high-risk genetic changes.
Normal FISH means no high-risk chromosomal abnormalities were found, which generally suggests a more favorable outlook.
IgG myeloma is the most common type, and combined with normal FISH results, this is considered a more standard-risk profile. Your care team will use this information to guide your treatment plan.
It's always worth asking your doctor to walk through what this means specifically for your treatment path — you deserve clear answers!
July 11
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