Hi Becky,
I am Smoldering (SMM). Have you been diagnosed with a bone marrow biopsy? You are fortunate that you live close enough to go to MM Specialists at Fred Hutchinson in Seattle. I have added you to my team. You are welcome to add me to yours.
Paula🌹
June 1
Smoldering multiple myeloma (SMM) is a precancerous condition that sits between a milder condition called MGUS and active multiple myeloma. It involves having too many abnormal plasma cells and elevated levels of M protein in the blood, but without any noticeable symptoms or organ damage.
Think of it as myeloma that hasn't Show Full Answer
Smoldering multiple myeloma (SMM) is a precancerous condition that sits between a milder condition called MGUS and active multiple myeloma. It involves having too many abnormal plasma cells and elevated levels of M protein in the blood, but without any noticeable symptoms or organ damage.
Think of it as myeloma that hasn't "woken up" yet — hence the name "smoldering." Because SMM has no symptoms, it's often discovered accidentally during routine blood tests. Signs that doctors look for include:
- High levels of M protein in the blood or urine
- Too many plasma cells in the bone marrow
- No signs of organ damage (like bone lesions or kidney problems) The risk of SMM progressing to active myeloma decreases over time:
- First 5 years: about 10% chance per year
- Years 5–10: drops to around 3% per year
- After 10 years: roughly 1% per year
Certain factors can increase the risk of progression, such as high M protein levels, a large number of plasma cells, or specific genetic changes in those cells. Treatment approaches for SMM vary. Some doctors recommend "watchful waiting" — regular monitoring without treatment — to avoid unnecessary side effects. However, for those with high-risk SMM, earlier treatment may be beneficial. Medications like Revlimid (lenalidomide) and bone-strengthening drugs like Zometa or Xgeva are sometimes used.
It's always worth having an open conversation with a specialist about which approach makes the most sense for your specific situation.
June 1
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