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Is anyone in this group on Hizentra for secondary immunodeficiency issues? https://www.hizentra.com/pi/why-hizentra/faqs/?msclkid=75d4cb7cc8

A MyMyelomaTeam Member asked a question 💭
Mount Joy, PA

I am planning to start this treatment in May for IgG numbers that are falling well below 300 and IgA numbers that are pushing 950. I am always sick with one infection or another.

Frequently Asked Questions | HIZENTRA® Immune Globulin Subcutaneous (Human) 20% Liquid
Frequently Asked Questions | HIZENTRA® Immune Globulin Subcutaneous (Human) 20% Liquid
https://www.hizentra.com/pi/why-hizentra/faqs/?msclkid=75d4cb7cc8
April 29
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Answer Summary

Members responded to a question about Hizentra for secondary immunodeficiency, sharing their own experiences with immune treatments and... Read more

Members responded to a question about Hizentra for secondary immunodeficiency, sharing their own experiences with immune treatments and frequent infections related to multiple myeloma. Several members described getting monthly IVIG infusions, noting it helps boost their immune systems, with one member also taking acyclovir to help prevent infections. A recurring theme was curiosity about whether subcutaneous injections like Hizentra are as effective as traditional infusions, along with warm encouragement for the member planning to start treatment in May.

A MyMyelomaTeam Member

I get IVIG monthly.

April 30
A MyMyelomaTeam Member

Thanks for the encouragement... I am eager to start the ivig...

April 30
A MyMyelomaTeam Member

I get IVIG monthly. It really helps my immune system. Hizentra is just another brand but you may be able to inject yourself instead of sitting In An infusion chair for 2 hours.

April 30
A MyMyelomaTeam Member

I get regular infusions of gamma globulin. Maybe that's why I get few infections, at least compared to the amount I used to get. My question is, are the subcutaneous injections as effective as the infusions?
Of course, dosages can surely be adjusted.
May God bless you!
Donnie

April 29
MyMyelomaTeam

Starting Hizentra (subcutaneous immunoglobulin) for secondary immunodeficiency related to myeloma is something other members have explored. It's used to help replace low IgG levels, which can drop significantly due to myeloma itself and its treatments.

Low IgG (below 300 is quite low!) leaves the body very vulnerable to Show Full Answer

Starting Hizentra (subcutaneous immunoglobulin) for secondary immunodeficiency related to myeloma is something other members have explored. It's used to help replace low IgG levels, which can drop significantly due to myeloma itself and its treatments.

Low IgG (below 300 is quite low!) leaves the body very vulnerable to repeated infections — so it makes complete sense that this is being addressed proactively. Several myeloma treatments are known to contribute to falling immunoglobulin levels, including:

- Immunomodulatory drugs like lenalidomide or pomalidomide
- Chemotherapy drugs such as proteasome inhibitors
- Steroids like dexamethasone
- Stem cell transplantation

It's worth discussing with the care team how Hizentra fits alongside any current treatment plan, and whether any adjustments are needed once infusions begin.

Connecting with others on MyMyelomaTeam who have experience with immunoglobulin replacement therapy could be really valuable — their firsthand insights can be incredibly helpful going into May! 💪

April 29

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