I’ve never had a double MSpike at the same time.

Since I was originally IgA Kappa, I’ve noticed three cases where I had an IgG MSpike.

In the first case, it was during Induction where the DarzFasPro had created a False MSpike that in the SPEP it was reported as 0.1 MSpike but when a SIEP was checked, it showed that it was in the IgG Band and actually False. Once they got me the Lab test #123218, it confirmed the IgG MSpike of 0.1 did not really exist.

That happened in 2021/2022. Once they realized my MSpike was False they got me the Blood Test clonoSEQ and found that I was MRD Negative (May 2022), at which time I then immediately discontinued All MM Meds, for Labs Monitoring Only.

Later in 2024 and recently in 2026, I had extremely low MSpikes of 0.04 and then 0.05. These separate instances were only in the IgG band. Since I was still MRD Negative, there was no actual IgA at that time.

Again for people who are IgA, many things like Covid shots, Vaccines, EvuSheld and others can cause a MSpike in the IgG band - these are going to be low and for only a few months.

My most recent False MSpike in the IgG band 2026 was due to the Flu that I caught. They referred to it as a Super Flu. It was 0.05 for one month, 0.03 the next and I’m expecting it will be gone later this month with my next Labs.

For people who are IgG, the above can cause False MSpikes that may go unnoticed, especially if a person is currently MM Active.

The most important thing to know is that DarzFasPro, and other mAb Meds will create a False MSpike, typically up to 0.2, that requires the Lab test # 123218 to cancel it, to realize that it’s not your IgG MM Activity.

I think @A MyMyelomaTeam Member had a double M spike. Check with him.
Paula🌹

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A MyMyelo...

Larry,
I knew you would know the answer! Thank you.
Paula 🌹