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At times my legs feel as though they are giving out. My skin itches like crazy. Are these signs of progression?

April 15
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A MyMyelomaTeam Member

Angela,
I am Smoldering too. My skin is dry and itchy. I figured it was from my kidneys. MM affects the kidneys. Drink more pure water. I also use Gold Bond diabetic lotion. Sarna lotion is great for the itch. My legs started giving out on me in 2020. They still do so I now have a walker if I have to walk too far or stand. What helped the most was when I started heart medication. You might want to see a Cardiologist. I was also tested for amyloidosis. MM can cause amyloidosis, which affects the heart. I see my Hematologist/Oncologist (a MM Specialist) every 3 months for blood tests and check up. You should also.
Paula🌹

April 17
A MyMyelomaTeam Member

Angela, yes these symptoms could be a sign of progression. Make sure you are seeing a myeloma specialist and are getting checked routinely.

April 17
A MyMyelomaTeam Member

Angela,
I want to add, my pelvis is deteriorating, so sometimes my left leg will collapse without warning. What is helping with that is supplements to keep my bones healthy and strong. I take MRM Bone Maximizer III which is Calcium and Magnesium. I take extra D3 to absorb the calcium, vitamin K2 which tells the calcium to go to the bones, and vitamins C, A and E complex, which all support absorption of calcium.and thin the blood. K2 can thicken the blood, but it’s super important for our bones. Have you had a scan recently?
Paula🌹

April 20
MyMyelomaTeam

Are leg weakness and intense itching signs that smoldering myeloma is progressing?

These symptoms could potentially indicate progression, but they're not definitive on their own. It's really important to discuss these changes with your doctor soon.

Leg weakness can occur when myeloma becomes more active. As the disease Show Full Answer

Are leg weakness and intense itching signs that smoldering myeloma is progressing?

These symptoms could potentially indicate progression, but they're not definitive on their own. It's really important to discuss these changes with your doctor soon.

Leg weakness can occur when myeloma becomes more active. As the disease progresses, it can cause bone damage and affect mobility. A MyMyelomaTeam member described similar experiences with leg pain and weakness that made daily activities challenging.

Itchy skin can happen with myeloma for a couple reasons:

- It may be related to the disease itself, as abnormal plasma cells can trigger immune responses that affect the skin
- It can sometimes indicate disease activity

However, smoldering myeloma typically doesn't cause symptoms, which is what makes it "smoldering." When symptoms like bone pain, weakness, or other issues develop, it may signal progression to active multiple myeloma.

Your healthcare team can run blood tests and other evaluations to check:

- M protein levels
- Plasma cell counts in bone marrow
- Calcium levels
- Kidney function
- Signs of bone damage

These tests will help determine whether your smoldering myeloma is progressing or if your symptoms have another cause. Don't wait to reach out to your doctor about these changes.

April 15

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