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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
March 8
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A MyMyelomaTeam Member

I didn't have any mobility issues when I was on KPD. Kyprolis did make my blood pressure go up. Let you doctor know as soon as possible.

March 9
A MyMyelomaTeam Member

Hi Ferzin,

Thank you for sharing your question

Treatments like KPD (Kyprolis, Pomalyst, and Dexamethasone) can sometimes cause fatigue, muscle weakness, or nerve effects. Because of this, some patients notice difficulty lifting their legs near the pelvic area or changes in walking. Other factors, like bone involvement or nerve pressure from myeloma, can also play a role.

It’s important to tell your doctors about any new weakness or changes in walking. They can assess muscle strength, nerves, and bones, and provide support to help you feel stronger. Many patients experience temporary weakness during treatment, but your team can guide you safely.

You are not alone, stay strong and hope your medical team helps you regain strength and confidence soon. 🙏

Not a doctor, just a myeloma patient sharing experience and support.
💪🩸🙏
Moh

March 8
MyMyelomaTeam

Can KPD treatment affect walking and cause difficulty lifting legs near the pelvis?

While the search results don't specifically mention KPD treatment, difficulty walking and lifting legs can occur with myeloma for several reasons:

Common causes of leg weakness and walking difficulty
* Peripheral neuropathy from myeloma Show Full Answer

Can KPD treatment affect walking and cause difficulty lifting legs near the pelvis?

While the search results don't specifically mention KPD treatment, difficulty walking and lifting legs can occur with myeloma for several reasons:

Common causes of leg weakness and walking difficulty:
* Peripheral neuropathy from myeloma treatments, which can cause numbness, tingling, and weakness in the legs
* Bone damage or lesions in the pelvis or spine from myeloma
* Spinal cord compression from vertebrae fractures, which can cause leg weakness or numbness
* Muscle cramps as a side effect of certain treatments

A MyMyelomaTeam member described similar symptoms: "The neuropathy weakens my legs and gives me pins-and-needles pain down both of my legs."

If you're experiencing sudden or severe difficulty lifting your legs or walking, especially with back pain, this could indicate spinal compression and requires immediate medical attention.

It's important to discuss these symptoms with your healthcare team. They can determine the specific cause and recommend appropriate treatments, which might include physical therapy, pain management, or adjustments to your treatment plan.

March 8

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