Why is immunofixation showing IgG kappa when your myeloma is IgA kappa?
You're absolutely right that the IgG kappa showing up on your immunofixation test is likely from the daratumumab treatment, not your actual myeloma. This is a known interference that happens with this medication.
Daratumumab is a monoclonal antibody Show Full Answer
Why is immunofixation showing IgG kappa when your myeloma is IgA kappa?
You're absolutely right that the IgG kappa showing up on your immunofixation test is likely from the daratumumab treatment, not your actual myeloma. This is a known interference that happens with this medication.
Daratumumab is a monoclonal antibody treatment that can show up on immunofixation tests as IgG kappa. This can make it look like there's a different type of M protein present, even though your actual myeloma remains IgA kappa.
The good news is that your IgA levels are normal, which suggests your IgA kappa myeloma is well-controlled. Your medical team is likely aware of this daratumumab interference and will use other tests to track your actual disease activity.
Your doctors may rely more on other monitoring methods like:
* Serum free light chain testing
* Quantitative immunoglobulin tests specifically for IgA
* Other markers that aren't affected by the daratumumab
This interference is expected and doesn't mean your myeloma type has changed or that something is wrong with your treatment.
March 4
Thank you very much Larry2
March 5
Get the Lab test #123218
This correctly cancel out the False MSpike.
If you then have No MSpike, get the Blood Sample clonoSEQ MRD Test. If it shows MRD Negative (None per Million Cells Tested), then you’re in Complete Remission
For myself while I’m MRD Negative, I remain on No MM Meds, now for the past 2-1/2 years
I was originally IgA, 5915 Kappa, 208 K/L Ratio and t4;14 high risk - that’s all a thing of the past
March 4
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