What are the stages of multiple myeloma?
Multiple myeloma is staged using the Revised International Staging System (R-ISS), which classifies the disease into three stages based on blood test results, protein levels, and genetic changes in cancer cells.
Stage 1 Multiple Myeloma
- The earliest and least advanced stage
- Show Full Answer
What are the stages of multiple myeloma?
Multiple myeloma is staged using the Revised International Staging System (R-ISS), which classifies the disease into three stages based on blood test results, protein levels, and genetic changes in cancer cells.
Stage 1 Multiple Myeloma:
- The earliest and least advanced stage
- Cancer progresses slowly with low numbers of myeloma cells
- Many people may not have symptoms yet
- Testing shows minimal signs of disease
- Treatment may be delayed until symptoms develop or test results show high risk for progression
Stage 2 Multiple Myeloma:
- Falls between stages 1 and 3 in severity
- Test results show more disease progression than stage 1 but less severe than stage 3
- Symptoms may include bone pain, fatigue, and frequent infections
Stage 3 Multiple Myeloma:
- The most advanced stage
- People are most likely to experience myeloma symptoms
- Defined by higher levels of beta-2 microglobulin and either high-risk genetic findings or elevated LDH levels
- May require alternative treatments or clinical trials
The stage assigned at diagnosis typically remains the same even if the disease relapses, though any relapse is considered higher risk.
February 22
Join
Your Privacy Choices
