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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMyelomaTeam Member asked a question 💭
Long Lane, MO

My husband has lymphedema which is also incurable. He has to wear compression everything.
Is this all related to MM?

January 31
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Reactions
A MyMyelomaTeam Member

So sorry he is dealing with this issue.

January 31
A MyMyelomaTeam Member

Thank you JoyLagasse . I have read alot about this and I believe his started after he had this broken femur. The swelling was so much. We have him in compression shorts and legs. Hoping this keeps it all in check. He is not happy about wearing this forever! With MM who knows how long that will be.

January 31
A MyMyelomaTeam Member

Lymphedema itself is NOT caused by
MM directly, but MM and its treatments can contribute to it or worsen it.

✔️ Ways MM can be related:Protein overload / fluid shifts from myeloma affecting circulationKidney involvement → fluid retention and swellingAmyloidosis (sometimes linked with MM) can cause severe swelling
Low albumin levels → fluid leaks into tissues
Infections (more common in MM) can damage lymph vessels

Treatment-related causes:
Steroids (dexamethasone) → fluid retention
Chemotherapy can damage lymphatic flow over time
Immobility or neuropathy → poor lymph drainage
Radiation or surgery (if applicable) can disrupt lymph nodes

🌸 In Simple Terms for the Group

Lymphedema isn’t always caused by MM, but MM can set the stage for it to develop or worsen.
Management is about control and protection, not cure.

Judy, you’re doing the right thing by advocating for him.
If you want, I can help you phrase follow-up questions for his doctor or explain signs that need urgent attention 🌿🙏

January 31
A MyMyelomaTeam Member

Hi Judy, I found the following article on lymphedema that suggests it could be related to cancer therapy or the cancer itself. You will see it is geared a bit toward the edema developed following breast cancer, but has enough general information that might be helpful.
https://thetutuproject.com/lymphedema-101-a-pri...

Lymphedema 101: A Primer on all You Need To Know - The Tutu Project
Lymphedema 101: A Primer on all You Need To Know - The Tutu Project
January 31
MyMyelomaTeam

Is lymphedema related to multiple myeloma?

Lymphedema isn't typically listed as a direct complication of multiple myeloma itself. However, myeloma can cause fluid retention and swelling (edema) in the legs, ankles, and other areas through a different mechanism.

As myeloma progresses, abnormal proteins and high calcium Show Full Answer

Is lymphedema related to multiple myeloma?

Lymphedema isn't typically listed as a direct complication of multiple myeloma itself. However, myeloma can cause fluid retention and swelling (edema) in the legs, ankles, and other areas through a different mechanism.

As myeloma progresses, abnormal proteins and high calcium levels in the blood can impair kidney function. This kidney damage can lead to fluid retention, causing noticeable swelling in areas like the ankles, legs, and abdomen.

Managing this type of swelling usually involves:
- Addressing underlying kidney issues
- Modifying fluid intake
- Sometimes using medications to reduce fluid retention

It's important to work with your husband's healthcare team to determine the specific cause of his swelling and whether it's related to his myeloma, kidney function, or another condition. They can help develop the best management plan for his situation.

January 31

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A MyMyelomaTeam Member asked a question 💭
Cathedral City, CA