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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
December 30, 2025
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A MyMyelomaTeam Member

My oncologist recommended topical magnesium (lotion or cream). A friend has recommended plain yellow mustard (keep packets in your car/purse from fast food places). It has worked for me.
Debbie, tryig to find your original message to me. Linda Menzel

December 31, 2025
A MyMyelomaTeam Member

Debbie, Unfortunately, the leg cramps are pretty common. I think they come with MM and not from the treatments. I had them before my official diagnosis, and through the induction therapy. They lessened greatly after the stem cell transplant, but started up again when I started to relapse.

December 31, 2025
MyMyelomaTeam

Have you experienced night sweats and muscle cramps in your hands and legs while taking Velcade?

Yes, other MyMyelomaTeam members have shared similar experiences. One member described having "lots of cramps in hands and calves" that would wake them up at night, leaving them more tired during the day.

Night sweats can Show Full Answer

Have you experienced night sweats and muscle cramps in your hands and legs while taking Velcade?

Yes, other MyMyelomaTeam members have shared similar experiences. One member described having "lots of cramps in hands and calves" that would wake them up at night, leaving them more tired during the day.

Night sweats can contribute to muscle cramps by depleting electrolytes like salt, potassium, and magnesium through heavy sweating. As one member noted, "If you sweat a lot at night, like many of us do, it might be your potassium level."

Some myeloma treatments, including certain chemotherapy drugs, can cause peripheral neuropathy which may lead to muscle spasms and cramping. Members have reported that their oncologists made changes to treatment plans that helped reduce severe muscle cramps.

Here are some approaches that have helped other members:

- Taking magnesium citrate and electrolytes
- Using muscle relaxants at night (prescribed by doctor)
- Staying well hydrated
- Applying heating pads to cramped areas
- Getting up and walking when cramps occur

It's important to discuss these symptoms with your oncology team. They can check your electrolyte levels and determine if adjustments to your treatment plan or additional medications might help manage these side effects.

December 30, 2025

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