Yes, what Donna said. I take Dartzalex Faspro, Dexamethasone, Revlimid, and Velcade,

@A MyMyelomaTeam Member

Hi Eli,

I also had the same treatment as Joy... DarzalexFaspro, Dexamethasone, Revlimid, and Velcade. As for the term Chemotherapy, many people most likely think of side effects like severe nausea and hair loss when they hear the word Chemotherapy. I did not experience these side effects as these newer medicines are not as harsh. Below is a question I asked ChatGPT and following is Chat's answer. When you have time read the whole thing. It gives a lot of hope. And that modern medicine has improved greatly for Multiple Myeloma.

This is the question I asked ChatGPT:
I think I read an article that multiple myeloma treatment with Dartzalex Faspro, Dexamethasone, Revlimid, and Velcade, maybe considered a cure in the future because people who had this treatment are staying in remission

ChatGPT response:
You did read something grounded in real trends — and you’re remembering correctly that this specific combination (Daratumumab Faspro + Revlimid + Velcade + Dexamethasone) is producing very long remissions in many patients. Some researchers even use terms like “functional cure” or “operational cure” when patients remain in deep remission for many years.

Let me break it down clearly — and safely — because “cure” is still not an official word in multiple myeloma, but the data is very encouraging.

✅ Why this combination is getting attention

Your regimen is often called Dara-RVd (Daratumumab + Revlimid + Velcade + Dexamethasone). It has become one of the leading frontline therapies for newly diagnosed multiple myeloma.

What studies are showing

Clinical trials such as GRIFFIN, PERSEUS, and ALCYONE show:

Much deeper responses compared to older regimens

Very high rates of MRD negativity (minimal residual disease) — meaning almost no detectable cancer cells

Some patients remaining in remission 7–10+ years

End of part 1
Continue to part 2 in the next post --->

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A MyMyelo...

@A MyMyelomaTeam Member

Part 2

Fewer relapses during early and mid-term follow-up

Researchers noticing that patients with sustained MRD negativity behave almost like the disease is functionally cured

Because multiple myeloma historically always came back, this is a major shift.

✅ What doctors mean by “functional cure”

Researchers avoid saying “cure,” but they do say:

“If MRD remains negative for many years, the patient may be considered functionally cured.”

That means:

No signs of disease

No symptoms

No progression

Living a normal lifespan

No ongoing need for heavy treatment (some patients stay only on maintenance Revlimid)

There are now patients on Dara-RVd who are still in remission over a decade later.

⭐ Why Darzalex Faspro is a game-changer

Daratumumab is one of the first therapies proven to:

Eliminate myeloma cells extremely effectively

Boost the immune system’s ability to keep the disease suppressed

Make other drugs (like Revlimid and Velcade) work better together

This synergy is why long-term remission is becoming more common.

🌟 Is multiple myeloma becoming curable?

Experts cautiously say:

We are not at a guaranteed cure today

But for some people, long-lasting remission is so deep and durable that it resembles a cure

Every major cancer center now uses Dara-RVd as standard of care because outcomes are so strong

With continuing maintenance therapy (such as Revlimid), many patients maintain remission long-term

Some hematologists believe that in the next 5–10 years, cure may become a realistic word for certain patients.

Vicki7

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A MyMyelo...

Wow, Vicki, thanks for that information! Very informative and encouraging. My light chains dropped from 118 to 20 after the first cycle. I've been sick with a respiratory virus for a couple weeks so haven't started the second cycle yet, but even missing a couple weeks treatment the light chains dropped a little further to 14. This combo is reallu good.

Myeloma is now initially treated with a four drug induction protocol. Or what ever is appropriate for a given patient depending on their other comorbidities, frailty etc. They are doing clinical trials for high risk smoldering myeloma patients. But usually, they don't start treatment until the myeloma is causing issues. Dana Faber is also doing dietary studies to see if a plant based diet can keep myeloma at bay.