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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
November 1, 2025
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Have you or others experienced tremors or shaky legs while on Revlimid, Dara, and Dex?

Yes, tremors can occur with these medications. Tremors are listed as a side effect that affects some people taking lenalidomide (Revlimid), occurring in at least 20 percent of patients. Shaky legs and muscle-related symptoms are Show Full Answer

Have you or others experienced tremors or shaky legs while on Revlimid, Dara, and Dex?

Yes, tremors can occur with these medications. Tremors are listed as a side effect that affects some people taking lenalidomide (Revlimid), occurring in at least 20 percent of patients. Shaky legs and muscle-related symptoms are recognized complications of this treatment combination.

Muscle spasms and cramps in the legs are also commonly reported side effects. Some MyMyelomaTeam members have shared experiencing severe muscle cramps in their legs, feet, and hands while on similar treatment regimens.

The combination of immunomodulatory drugs like Revlimid with other treatments can affect muscle tissue and parts of the central nervous system, which may contribute to tremors and shakiness.

It's important to report these symptoms to your oncologist. They may be able to adjust your treatment plan or suggest ways to manage these side effects, as some members found that treatment modifications helped reduce their symptoms significantly.

November 1, 2025

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