MyMyelomaTeam

In myeloma patients, IgM levels can be affected when abnormal plasma cells crowd out healthy plasma cells. IgM antibodies normally act as first responders in the blood and lymph system to help identify and remember previous infections. When myeloma cells take over, they typically produce only one type of antibody (usually Show Full Answer

In myeloma patients, IgM levels can be affected when abnormal plasma cells crowd out healthy plasma cells. IgM antibodies normally act as first responders in the blood and lymph system to help identify and remember previous infections. When myeloma cells take over, they typically produce only one type of antibody (usually IgG or IgA) instead of a healthy variety of antibodies.

This can lead to reduced production of other important antibodies like IgM, even without showing monoclonal bands. The lack of monoclonal bands specifically for IgM makes sense since IgM myeloma is very rare.

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