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Muskego, WI
August 19, 2025
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Multiple myeloma staging is determined using the Revised International Staging System (R-ISS), which looks at blood test results, protein levels, and genetic changes in cancer cells. Unlike other cancers, myeloma staging is unique because it's a blood cancer that affects the entire system rather than having a specific tumor Show Full Answer

Multiple myeloma staging is determined using the Revised International Staging System (R-ISS), which looks at blood test results, protein levels, and genetic changes in cancer cells. Unlike other cancers, myeloma staging is unique because it's a blood cancer that affects the entire system rather than having a specific tumor location.

Here are the three stages:

• Stage 1: The earliest stage with minimal signs of myeloma and low cancer cell levels. Some people may not have symptoms yet.

• Stage 2: More advanced disease with possible symptoms like bone pain, fatigue, and frequent infections. Test results show more progression than Stage 1.

• Stage 3: The most advanced stage with higher levels of disease markers and more severe symptoms. As one MyMyelomaTeam member noted, "Staging is very different for myeloma. It's not based on what needs to be done... it's based on how much of your body is affected." Doctors use this staging information to guide treatment decisions and determine the most effective options for each individual.

August 19, 2025

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