MyMyelomaTeam

Doctors now use the Revised International Staging System (R-ISS) to classify multiple myeloma, which divides the disease into three distinct stages. This staging system is based on several factors including:

• Blood test results
• Protein levels
• Genetic changes in cancer cells Unlike other cancers where staging is based Show Full Answer

Doctors now use the Revised International Staging System (R-ISS) to classify multiple myeloma, which divides the disease into three distinct stages. This staging system is based on several factors including:

• Blood test results
• Protein levels
• Genetic changes in cancer cells Unlike other cancers where staging is based on tumor size and spread, multiple myeloma staging is unique because it's a blood cancer that is systemic by nature. The staging focuses on factors like:

• Bone damage
• Beta-2 microglobulin (B2M) levels
• Abnormal protein levels

This helps doctors guide treatment decisions, though staging provides less direct information about prognosis compared to solid tumors.

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