March, I also worked around radiation. I worked on a unit that had patients with radioactive implants. I don't know if it was the cause of mine.

Thank you Donna. In my case I feel radiation for breast cancer may have been a factor in my MM. just my opinion .

there isn't a single "myeloma gene," genetic factors play a role in the development of multiple myeloma. Research suggests that mutations in certain genes, like FAM46C, BRAF, RAS, and MYC, can increase the risk of developing the disease. Additionally, some individuals may inherit genetic predispositions that increase their susceptibility.
Elaboration:
Genetic Mutations:
Multiple myeloma is caused by genetic mutations in plasma cells, leading them to become cancerous. These mutations can involve oncogenes (like MYC, NRAS, and KRAS) or tumor suppressor genes.
Inherited Predisposition:
While the mutations that cause multiple myeloma are not typically inherited, some individuals may inherit a slightly increased risk due to genetic factors. This is supported by family history, where individuals with a parent or sibling who has had myeloma are more likely to develop it themselves.
Specific Genes:
FAM46C: Mutations in this gene, which is involved in ribosomal protein synthesis, have been linked to multiple myeloma.
BRAF: Mutations in this gene, which regulates cell growth, have also been identified in myeloma cases.
RAS: Mutations in these genes, including NRAS and KRAS, are frequently observed in myeloma and are associated with disease progression.
MYC: Activation of this oncogene is a common genetic change in myeloma and can contribute to tumor growth.
BRCA1 and BRCA2:
Research has also linked inherited differences in these genes to an increased risk of multiple myeloma in some individuals.
Chromosomal Abnormalities:
In many cases of multiple myeloma, there are chromosomal translocations, particularly involving chromosome 14.

My sisters did get tested for myeloma. Since I have myeloma and my sister has the precursor.

No, there is no carrier gene for myeloma, that I have ever read about. Which gene are you referring to? Myeloma clones can carry tumor suppresor gene that can make our myeloma harder to treat. But these genes are genes our myeloma cells acquire over time. They are not genes we are born with. My sister and I did see a genetic specialist. I have myeloma, and she has MGUS. They didn't find anything. We both carry the trait for Faconi anemia, which is another blood disorder. It's interesting, but it shouldn't cause myeloma.